Fuchs Endothelial Cornea Dystrophy: A Review of the Genetics Behind Disease Development
نویسندگان
چکیده
منابع مشابه
Confocal microscopy in cornea guttata and Fuchs' endothelial dystrophy.
AIMS To report the appearances of cornea guttata and Fuchs' endothelial dystrophy from white light confocal microscopy. METHODS Seven eyes of four consecutive patients with cornea guttata were prospectively examined. Of the seven eyes, three also had corneal oedema (Fuchs' dystrophy). In vivo white light tandem scanning confocal microscopy was performed in all eyes. Results were compared with...
متن کاملCornea Fuchs’ Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy
V. Vinod Mootha, Brock Hansen, Ziye Rong, Pradeep P. Mammen, Zhengyang Zhou, Chao Xing, and Xin Gong Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, United States McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States Department of Internal Medicine, University of Texas Southwe...
متن کاملThe role of apoptosis in the pathogenesis of Fuchs endothelial dystrophy of the cornea.
OBJECTIVE To investigate the potential role of apoptosis in the pathogenesis of Fuchs endothelial dystrophy of the cornea. METHODS Twenty-one corneal buttons from patients with Fuchs dystrophy and 15 control corneas were studied. Apoptosis was assessed by the in situ end-labeling of double-stranded DNA breaks, and by immunohistochemical characterization of cellular markers associated with apo...
متن کاملEndothelial keratoplasty for Fuchs dystrophy
We report the case of a 69-year-old female with Fuchs endothelial dystrophy and posterior chamber in-the-bag intraocular lens, whom we treated with DMEK surgical technique. We encountered difficulties both during obtaining the endothelium from the young donor and during the intraocular unrolling and its application on the stroma. We evaluated both preoperative and postoperative the following pa...
متن کاملFuchs endothelial corneal dystrophy: current perspectives.
Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet's membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress ...
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ژورنال
عنوان ژورنال: Seminars in Ophthalmology
سال: 2013
ISSN: 0882-0538,1744-5205
DOI: 10.3109/08820538.2013.825283